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KMID : 0880220120500050869
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Journal of Microbiology
2012 Volume.50 No. 5 p.869 ~ p.873
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Envelope diversity, characteristics of V3 region and predicted co-receptor usage of human immunodeficiency viruses infecting north indians
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Raiees Andrabi
Rajesh Kumar
Manju Bala
Ambili Nair
Prakash SS
Vandana Kushwaha
Kalpana Luthra
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Abstract
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Subtypes of human immunodeficiency virus type 1 circulating in 21 north Indian patients were characterized based on the partial sequence of the gp120 envelope protein. A majority of viruses (85.7%, 18/21) were subtype C, while 14.3% (3/21) were subtype A. Sequence analysis revealed that the V3 region was highly conserved compared with V4 and V5. The predicted use of co-receptors indicated exclusive usage of R5, except for two subtype A viruses (AIIMS279 and AIIMS281). Our results demonstrate conservation within the V3 loop of subtype C viruses, and suggest the emergence of non-clade C viruses in the north Indian population.
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KEYWORD
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HIV-1, subtypes, envelope glycoprotein, variable regions, co-receptor usage
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